ULVAC, Inc. ULVAC Solutions for μPD (Micro-Powder Dry) system

"Leading Edge Process for Lyophilization"

The powder that is obtained using conventional lyophilization technologies, such as a freeze-drying and a spray-drying, presents problems like differences in concentration, low solubility, and inhomogeneity.
We, ULVAC, have solved those problems, utilizing the technology that renders liquids directly dry. Then, we also incorporate a fully packaged process system for sterile production including powder filling and capping. Apply to not only pharmaceuticals, but also food processing, fine chemicals and electrical materials.

Utilizing Sublimation

Sublimation that is the process of immediate transition of a substance from the solid-state to the gas-state, is utilized in µPD. Therefore, spherical shape powder by self-freezing in air under vacuum is obtained, so that the process of µPD is an epoch-making one as a novel lyophilization technology.

Main Features

The µPD has the unique technologies that consist of a water particle generation, a self-freezing and others.

Sprays stock solution using a special nozzle.
Self-freezing occurs while falling.
Shelf heated to dry.

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Small particle sized and homogeneous powder production

High speed drying due to larger surface area of frozen material causes a very sharp profile of particle size distribution and no concentration gradient of powder. It means that these particles have high uniformity in particle size and very homogeneous concentration of powder by freezing from liquid droplet.

Marked reduciton in the manufacturing process

Additional production process like milling, classifying, etc. can be reduced.
Furthermore, very few loss and high process yield are carried out.

Superior Solubility

High speed drying due to larger surface area of frozen material, contributes to superior solubility.

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Line Up of µPD Series

	The μPD Series are the refined equipment using self-freezing in practical applications.

[Specifications]

	Equipment for Mass-production	Compact Equipment for Experiment
Model	µPD2000	µPD400
Particle size	100 to 400µm
Capacity	150L/Batch	5L/Batch
Shelf temperature control range	-50 to 60℃	-40 to 60℃
Vacuum control range	5 to 30Pa
Ｃold trap temperature	-65℃	-60℃
Required space[mm]	5600W×8200L×6800H	1600W×2150L×3300H

Turn Key System

Closed system of sterile pharmaceutical production is realized

■ Unit of Powder Filling up

[Specification]

Particle size	200 to 300µm
Vessel	φ24.3[vial-bottle]
Tact speed	2vials/(min･head) *100mg-filling up
Filling up volume	100 to 1000 mg
Accuracy	±0.5％

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	One of the most important application utilizing µPD is the sterile pharmaceutical production.
	Turn key system of µPD has been constructed aiming at advance into Global Market.
	Those technologies which contribute to novel pharmaceutical production using extremely small sized powder, are applied for not only conventional freeze dry processes（Lyophilization）but also general splay-dry and vacuum-dry ones.
	The µPD technology is also applicable for Health care materials, Foods, Cosmetics, and Electronic material productions as well as pharmaceutical one.