"Leading Edge Process for Lyophilization"
The powder that is obtained using conventional lyophilization
technologies, such as a freeze-drying and a spray-drying,
presents problems like differences in concentration, low
solubility, and inhomogeneity.
We, ULVAC, have solved those problems, utilizing the
technology that renders liquids directly dry. Then, we also
incorporate a fully packaged process system for sterile
production including powder filling and capping. Apply to
not only pharmaceuticals, but also food processing, fine
chemicals and electrical materials.
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Utilizing Sublimation
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Sublimation that is the process of
immediate transition of a substance
from the solid-state to the gas-state, is
utilized in µPD. Therefore, spherical
shape powder by self-freezing in air
under vacuum is obtained, so that the
process of µPD is an epoch-making one
as a novel lyophilization technology. |
Main Features
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The µPD has the unique technologies
that consist of a water particle generation,
a self-freezing and others.
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Small particle sized and homogeneous powder production
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High speed drying due to larger surface
area of frozen material causes a very
sharp profile of particle size distribution
and no concentration gradient of
powder. It means that these particles
have high uniformity in particle size and
very homogeneous concentration of
powder by freezing from liquid droplet. |
Marked reduciton in the manufacturing process
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Additional production process like milling, classifying, etc. can be reduced.
Furthermore, very few loss and high process yield are carried out. |
Superior Solubility
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High speed drying due to larger surface
area of frozen material, contributes to
superior solubility.
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Line Up of µPD Series
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The μPD Series are the refined equipment using self-freezing in practical applications. |
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[Specifications] |
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Equipment for
Mass-production |
Compact Equipment for
Experiment |
Model |
µPD2000 |
µPD400 |
Particle size |
100 to 400µm |
Capacity |
150L/Batch |
5L/Batch |
Shelf temperature control range |
-50 to 60℃ |
-40 to 60℃ |
Vacuum control range |
5 to 30Pa |
Cold trap temperature |
-65℃ |
-60℃ |
Required space[mm] |
5600W×8200L×6800H |
1600W×2150L×3300H
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Turn Key System
Closed system of sterile pharmaceutical production is realized |
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■ Unit of Powder Filling up
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[Specification] |
Particle size |
200 to 300µm |
Vessel |
φ24.3[vial-bottle] |
Tact speed |
2vials/(min・head) *100mg-filling up |
Filling up volume |
100 to 1000 mg |
Accuracy |
±0.5% |
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| One of the most important application utilizing µPD is the sterile pharmaceutical production. |
| Turn key system of µPD has been constructed aiming at advance into Global Market. |
| Those technologies which contribute to novel pharmaceutical production using extremely small sized powder, are applied for not only conventional freeze dry processes(Lyophilization)but also general splay-dry and vacuum-dry ones. |
| The µPD technology is also applicable for Health care materials, Foods, Cosmetics, and Electronic material productions as well as pharmaceutical one. |
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